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1

DNA Interstrand Crosslinks: Natural and Drug-Induced DNA Adducts that Induce Unique Cellular Responses

Orlando D. Schärer

Journal:

Year:

2005

Language:

english

File:

PDF, 285 KB

english, 2005

2

Editorial: Closing the Gap between Chemistry and Biology

Orlando Schärer, Carsten Schultz

Journal:

Year:

2005

Language:

english

File:

PDF, 126 KB

english, 2005

3

A key interaction with RPA orients XPA in NER complexes

Topolska-Woś, Agnieszka M, Sugitani, Norie, Cordoba, John J, Le Meur, Kateryna V, Le Meur, Rémy A, Kim, Hyun Suk, Yeo, Jung-Eun, Rosenberg, Daniel, Hammel, Michal, Schärer, Orlando D, Chazin, Walter J

Journal:

Nucleic Acids Research

Year:

2020

Language:

english

File:

PDF, 4.89 MB

english, 2020

4

Single-molecule manipulation of double-stranded DNA using optical tweezers: Interaction studies of DNA with RecA and YOYO-1

Martin L. Bennink, Orlando D. Schärer, Roland Kanaar, Kumiko Sakata-Sogawa, Juleon M. Schins, Johannes S. Kanger, Bart G. de Grooth, Jan Greve

Journal:

Cytometry Part A

Year:

1999

Language:

english

File:

PDF, 332 KB

english, 1999

5

Recent progress in the biology, chemistry and structural biology of DNA glycosylases

Orlando D. Schärer, Josef Jiricny

Journal:

Year:

2001

Language:

english

File:

PDF, 390 KB

english, 2001

6

Chemie und Biologie der DNA-Reparatur

Orlando D. Schärer

Journal:

Angewandte Chemie

Year:

2003

Language:

german

File:

PDF, 963 KB

german, 2003

7

Chemistry and Biology of DNA Repair

Orlando D. Schärer

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 801 KB

english, 2003

8

DNA Damage Recognition. Edited by Wolfram Siede, Yoke Wah Kow and Paul W. Doetsch.

Orlando D. Schärer

Journal:

Year:

2006

Language:

english

File:

PDF, 29 KB

english, 2006

9

A Molecular Basis for Damage Recognition in Eukaryotic Nucleotide Excision Repair

Orlando D. Schärer

Journal:

Year:

2008

Language:

english

File:

PDF, 357 KB

english, 2008

10

Synthesis and Molecular Modeling of a Nitrogen Mustard DNA Interstrand Crosslink

Angelo Guainazzi, Arthur J. Campbell, Dr. Todor Angelov, Prof. Carlos Simmerling, Prof. Orlando D. Schärer

Journal:

Chemistry - A European Journal

Year:

2010

Language:

english

File:

PDF, 419 KB

english, 2010

11

Translesion DNA synthesis polymerases in DNA interstrand crosslink repair

The Vinh Ho, Orlando D. Schärer

Journal:

Environmental and Molecular Mutagenesis

Year:

2010

Language:

english

File:

PDF, 560 KB

english, 2010

12

Crosslinking of nucleotide excision repair proteins with DNA containing photoreactive damages

Ekaterina A. Maltseva, Nadejda I. Rechkunova, Irina O. Petruseva, Wim Vermeulen, Orlando D. Schärer, Olga I. Lavrik

Journal:

Bioorganic Chemistry

Year:

2008

Language:

english

File:

PDF, 552 KB

english, 2008

13

Chemical approaches toward understanding base excision DNA repair

Orlando D Schärer, Li Deng, Gregory L Verdine

Journal:

Current Opinion in Chemical Biology

Year:

1997

Language:

english

File:

PDF, 662 KB

english, 1997

14

Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy

Angelo Guainazzi, Orlando D. Schärer

Journal:

Cellular and Molecular Life Sciences

Year:

2010

Language:

english

File:

PDF, 627 KB

english, 2010

15

Wedging out DNA damage

Schärer, Orlando D, Campbell, Arthur J

Journal:

Nature Structural and Molecular Biology

Year:

2009

Language:

english

File:

PDF, 534 KB

english, 2009

16

Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA

Tsodikov, Oleg V, Ivanov, Dmitri, Orelli, Barbara, Staresincic, Lidija, Shoshani, Ilana, Oberman, Robert, Schärer, Orlando D, Wagner, Gerhard, Ellenberger, Tom

Journal:

The EMBO Journal

Year:

2007

Language:

english

File:

PDF, 304 KB

english, 2007

17

Synthese von DNA-Interstrang-Crosslinks unter Verwendung einer photoaktivierbaren Nucleobase

Sarah Hentschel, Dr. Jawad Alzeer, Dr. Todor Angelov, Prof. Dr. Orlando D. Schärer, Prof. Dr. Nathan W. Luedtke

Journal:

Angewandte Chemie

Year:

2012

Language:

german

File:

PDF, 509 KB

german, 2012

18

Synthesis of DNA Interstrand Cross-Links Using a Photocaged Nucleobase

Sarah Hentschel, Dr. Jawad Alzeer, Dr. Todor Angelov, Prof. Dr. Orlando D. Schärer, Prof. Dr. Nathan W. Luedtke

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 515 KB

english, 2012

19

The molecular basis for different disease states caused by mutations in TFIIH and XPG

Orlando D. Schärer

Journal:

Year:

2008

Language:

english

File:

PDF, 493 KB

english, 2008

20

Multistep damage recognition, pathway coordination and connections to transcription, damage signaling, chromatin structure, cancer and aging: Current perspectives on the nucleotide excision repair pathway

Orlando D. Schärer

Journal:

Year:

2011

Language:

english

File:

PDF, 97 KB

english, 2011

21

Regulation of endonuclease activity in human nucleotide excision repair

Adebanke F. Fagbemi, Barbara Orelli, Orlando D. Schärer

Journal:

Year:

2011

Language:

english

File:

PDF, 898 KB

english, 2011

22

Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily

Huw M. Nash, Steven D. Bruner, Orlando D. Schärer, Tomohiko Kawate, Theresa A. Addona, Eric Spooner, William S. Lane, Gregory L. Verdine

Journal:

Current Biology

Year:

1996

Language:

english

File:

PDF, 377 KB

english, 1996

23

Crosslinking of the NER damage recognition proteins XPC-HR23B, XPA and RPA to photoreactive probes that mimic DNA damages

Ekaterina A. Maltseva, Nadejda I. Rechkunova, Ludovic C. Gillet, Irina O. Petruseva, Orlando D. Schärer, Olga I. Lavrik

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2007

Language:

english

File:

PDF, 790 KB

english, 2007

24

Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair

Markus Räschle, Puck Knipscheer, Milica Enoiu, Todor Angelov, Jingchuan Sun, Jack D. Griffith, Tom E. Ellenberger, Orlando D. Schärer, Johannes C. Walter

Journal:

Year:

2008

Language:

english

File:

PDF, 1.35 MB

english, 2008

25

Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair

Markus Räschle, Puck Knipscheer, Milica Enoiu, Todor Angelov, Jingchuan Sun, Jack D. Griffith, Tom E. Ellenberger, Orlando D. Schärer, Johannes C. Walter

Journal:

Year:

2009

File:

PDF, 31 KB

2009

26

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

Yu V. Fu, Hasan Yardimci, David T. Long, Angelo Guainazzi, Vladimir P. Bermudez, Jerard Hurwitz, Antoine van Oijen, Orlando D. Schärer, Johannes C. Walter

Journal:

Year:

2011

Language:

english

File:

PDF, 1.50 MB

english, 2011

27

Achieving Broad Substrate Specificity in Damage Recognition by Binding Accessible Nondamaged DNA

Orlando D. Schärer

Journal:

Year:

2007

Language:

english

File:

PDF, 353 KB

english, 2007

28

Alkyltransferase-like Proteins: Brokers Dealing with Alkylated DNA Bases

Orlando D. Schärer

Journal:

Year:

2012

Language:

english

File:

PDF, 137 KB

english, 2012

29

Structural Basis for the Excision Repair of Alkylation-Damaged DNA

Jörg Labahn, Orlando D. Schärer, Alexander Long, Khosro Ezaz-Nikpay, Gregory L. Verdine, Tom E. Ellenberger

Journal:

Year:

1996

Language:

english

File:

PDF, 3.96 MB

english, 1996

30

Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA: Mechanisms for Nucleotide Flipping and Base Excision

Albert Y. Lau, Orlando D. Schärer, Leona Samson, Gregory L. Verdine, Tom Ellenberger

Journal:

Year:

1998

Language:

english

File:

PDF, 1.79 MB

english, 1998

31

Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair

Gillet, Ludovic C. J., Schärer, Orlando D.

Journal:

Chemical Reviews

Year:

2006

Language:

english

File:

PDF, 1.09 MB

english, 2006

32

Synthesis of Sequence-Specific DNA–Protein Conjugates via a Reductive Amination Strategy

Wickramaratne, Susith, Mukherjee, Shivam, Villalta, Peter W., Schärer, Orlando D., Tretyakova, Natalia Y.

Journal:

Bioconjugate Chemistry

Year:

2013

Language:

english

File:

PDF, 4.04 MB

english, 2013

33

Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair

Hodskinson, Michael R.G., Silhan, Jan, Crossan, Gerry P., Garaycoechea, Juan I., Mukherjee, Shivam, Johnson, Christopher M., Schärer, Orlando D., Patel, Ketan J.

Journal:

Year:

2014

Language:

english

File:

PDF, 3.18 MB

english, 2014

34

Investigation of the Mechanisms of DNA Binding of the Human G/T Glycosylase Using Designed Inhibitors

Orlando D. Schärer, Tomohiko Kawate, Paola Gallinari, Josef Jiricny and Gregory L. Verdine

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.40 MB

english, 1997

35

The Efficiencies of Damage Recognition and Excision Correlate with Duplex Destabilization Induced by Acetylaminofluorene Adducts in Human Nucleotide Excision Repair

Yeo, Jung-Eun, Khoo, Andy, Fagbemi, Adebanke F., Schärer, Orlando D.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 3.19 MB

english, 2012

36

Unusually Strong Binding of a Designed Transition-State Analog to a Base-Excision DNA Repair Protein

Deng, Li, Schärer, Orlando D., Verdine, Gregory L.

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 134 KB

english, 1997

37

Interconverting Conformations of Slipped-DNA Junctions Formed by Trinucleotide Repeats Affect Repair Outcome

Slean, Meghan M., Reddy, Kaalak, Wu, Bin, Nichol Edamura, Kerrie, Kekis, Mariana, Nelissen, Frank H. T., Aspers, Ruud L. E. G., Tessari, Marco, Schärer, Orlando D., Wijmenga, Sybren S., Pearson, Chris

Journal:

Year:

2013

Language:

english

File:

PDF, 1.97 MB

english, 2013

38

Preparation of C8-Amine and Acetylamine Adducts of 2‘-Deoxyguanosine Suitably Protected for DNA Synthesis

Gillet, Ludovic C. J., Schärer, Orlando D.

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 82 KB

english, 2002

39

Involvement of ERCC1/XPF and XPG in Oligodeoxynucleotide-directed Gene Modification

Igoucheva, Olga, Alexeev, Vitali, Scharer, Orlando, Yoon, Kyonggeun

Journal:

Oligonucleotides

Year:

2006

Language:

english

File:

PDF, 6.16 MB

english, 2006

40

The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability

Fattah, Farjana J., Hara, Kodai, Fattah, Kazi R., Yang, Chenyi, Wu, Nan, Warrington, Ross, Chen, David J., Zhou, Pengbo, Boothman, David A., Yu, Hongtao, Scharer, Orlando D.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.30 MB

english, 2014

41

FANCD2-associated Nuclease 1, but Not Exonuclease 1 or Flap Endonuclease 1, Is Able to Unhook DNA Interstrand Cross-links in Vitro

Pizzolato, Julia, Mukherjee, Shivam, Schärer, Orlando D., Jiricny, Josef

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 2.47 MB

english, 2015

42

Involvement of Translesion Synthesis DNA Polymerases in DNA Interstrand Crosslink Repair

Roy, Upasana, Schärer, Orlando D.

Journal:

Year:

2016

Language:

english

File:

PDF, 508 KB

english, 2016

43

Structure-Specific Endonucleases in DNA Repair

Schärer, Orlando D.

Journal:

CHIMIA International Journal for Chemistry

Year:

2009

Language:

english

File:

PDF, 552 KB

english, 2009

44

Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases

Wickramaratne, Susith, Ji, Shaofei, Mukherjee, Shivam, Su, Yan, Pence, Matthew G., Lior-Hoffmann, Lee, Fu, Iwen, Broyde, Suse, Guengerich, F. Peter, Distefano, Mark, Schärer, Orlando D., Sham, Yuk Yin

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 5.40 MB

english, 2016

45

The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase η

Roy, Upasana, Mukherjee, Shivam, Sharma, Anjali, Frank, Ekaterina G., Schärer, Orlando D.

Journal:

Nucleic Acids Research

Year:

2016

Language:

english

File:

PDF, 3.24 MB

english, 2016

46

Mutagenicity of a Model DNA-Peptide Cross-Link in Human Cells: Roles of Translesion Synthesis DNA Polymerases

Pande, Paritosh, Ji, Shaofei, Mukherjee, Shivam, Schärer, Orlando D., Tretyakova, Natalia Y., Basu, Ashis K.

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 1.28 MB

english, 2017

47

A new sub‐pathway of long‐patch base excision repair involving 5′ gap formation

Woodrick, Jordan, Gupta, Suhani, Camacho, Sharon, Parvathaneni, Swetha, Choudhury, Sujata, Cheema, Amrita, Bai, Yi, Khatkar, Pooja, Erkizan, Hayriye Verda, Sami, Furqan, Su, Yan, Schärer, Orlando D, S

Journal:

The EMBO Journal

Year:

2017

Language:

english

File:

PDF, 2.48 MB

english, 2017

48

ERCC1‐XPF endonuclease—positioned to cut

Schärer, Orlando D

Journal:

The EMBO Journal

Year:

2017

Language:

english

File:

PDF, 267 KB

english, 2017

49

Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway

Kato, Niyo, Kawasoe, Yoshitaka, Williams, Hannah, Coates, Elena, Roy, Upasana, Shi, Yuqian, Beese, Lorena S., Schärer, Orlando D., Yan, Hong, Gottesman, Max E., Takahashi, Tatsuro S., Gautier, Jean

Journal:

Year:

2017

Language:

english

File:

PDF, 1.98 MB

english, 2017

50

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response

Thompson, Elizabeth L., Yeo, Jung E., Lee, Eun-A, Kan, Yinan, Raghunandan, Maya, Wiek, Constanze, Hanenberg, Helmut, Schärer, Orlando D., Hendrickson, Eric A., Sobeck, Alexandra

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 12.53 MB

english, 2017